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Rank: Advanced Member
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 Laughing Gas Could Be Antidepressant AlternativeResearchers at Washington University in St. Louis have found that "laughing gas"— nitrous oxide, the mild sedative often used in dental procedures—can alleviate symptoms of clinical depression in patients who see few results with traditional antidepressant s. More than half of study participants who received nitrous oxide treatment felt a noticeable improvement in their symptoms after a day, and some reported complete remission. However, researchers say further studies are needed to replicate the results. More...
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Location: Tbilisi, T'bilisi, Georgia
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I have suffered from severe depressions in my late teenage years and early twenties and I know what it really means. My impression is that depression is rather a psychological problem and cannot be cured pharmaceutically. Antidepressant drugs may have only a placebo effect, I am afraid.
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Rank: Advanced Member
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An interesting study that deserves a better design with a lot more subjects (only 10 in each group, which calls into question some of their statistical claims) and a better control group (the placebo was nitrogen/oxygen rather that nitrous oxide/oxygen, so the subject clearly knew what group he/she was in.) If proven effective, the technique could provide dramatic widespread benefits.
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Doesn't nitrous oxide potentially cause irreversible brain damage?
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beats toothache
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the research keeps continuting that great
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GreenBanana wrote:Doesn't nitrous oxide potentially cause irreversible brain damage? It does, But you would just laugh about it 
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GreenBanana wrote:Doesn't nitrous oxide potentially cause irreversible brain damage? Nitrous oxide causes vitamin B12 deficiency. As a result, B12 deficiency can cause severe and irreversible neurological damage. In addition, homocysteine is a toxic amino acid that builds up when B12 is low. High homocysteine levels cause cardiovascular problems increasing the risk of atherosclerosis, hypertension, heart attack and stroke. High homocysteine is also associated with cerebral atrophy. References: "Everything You Want Your Doctor to Know about Vitamin B12" http://www.youtube.com/watch?v=BvEizypoyO0Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults. http://www.ncbi.nlm.nih.gov/pubmed/23343490Cobalamin deficiency: clinical picture and radiological findings. http://www.ncbi.nlm.nih.gov/pubmed/24248213Plasma vitamin B12 status and cerebral white-matter lesions. http://www.ncbi.nlm.nih.gov/pubmed/18977824Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. http://www.ncbi.nlm.nih.gov/pubmed/15879345The Role of B Vitamins in Preventing and Treating Cognitive Impairment and Decline http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648704/pdf/801.pdfAcceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. http://www.ncbi.nlm.nih.gov/pubmed/20005283Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. http://www.ncbi.nlm.nih.gov/pubmed/23690582Dr. Benjamin Lynch discusses the B12 and folate methylation cycles. https://www.youtube.com/watch?v=Mwn7RjSx3zM#t=120
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Boy oh boy, could I use some "gas" right about now.....
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Well, yes, it would be I suppose.
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lol lol
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This pilot study comprised only 20 patients. We're making a lot of inferences for such a small control group. Nevertheless, it sounds good so far. I've also suffered severe depression in my youth, but I'm inclined to believe it's more than merely psychological. Depression is a big killer, so it's something we need effective treatments for.
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