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Laughing Gas Could Be Antidepressant Alternative Options
Daemon
Posted: Monday, December 15, 2014 12:00:00 AM
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Laughing Gas Could Be Antidepressant Alternative

Researchers at Washington University in St. Louis have found that "laughing gas"—nitrous oxide, the mild sedative often used in dental procedures—can alleviate symptoms of clinical depression in patients who see few results with traditional antidepressant s. More than half of study participants who received nitrous oxide treatment felt a noticeable improvement in their symptoms after a day, and some reported complete remission. However, researchers say further studies are needed to replicate the results. More...
ChristopherJohnson
Posted: Monday, December 15, 2014 12:42:33 AM

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I have suffered from severe depressions in my late teenage years and early twenties and I know what it really means. My impression is that depression is rather a psychological problem and cannot be cured pharmaceutically. Antidepressant drugs may have only a placebo effect, I am afraid.
Dr WWWW
Posted: Monday, December 15, 2014 10:07:47 AM

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An interesting study that deserves a better design with a lot more subjects (only 10 in each group, which calls into question some of their statistical claims) and a better control group (the placebo was nitrogen/oxygen rather that nitrous oxide/oxygen, so the subject clearly knew what group he/she was in.) If proven effective, the technique could provide dramatic widespread benefits.
GreenBanana
Posted: Monday, December 15, 2014 10:11:24 AM

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Doesn't nitrous oxide potentially cause irreversible brain damage?
pedro
Posted: Monday, December 15, 2014 10:15:03 AM
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beats toothache
striker
Posted: Monday, December 15, 2014 11:56:18 AM
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the research keeps continuting that great
PDX1209
Posted: Monday, December 15, 2014 2:47:16 PM
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GreenBanana wrote:
Doesn't nitrous oxide potentially cause irreversible brain damage?


It does, But you would just laugh about it Dancing
Oscar D. Grouch
Posted: Monday, December 15, 2014 7:20:51 PM

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GreenBanana wrote:
Doesn't nitrous oxide potentially cause irreversible brain damage?

Nitrous oxide causes vitamin B12 deficiency. As a result, B12 deficiency can cause severe and irreversible neurological damage. In addition, homocysteine is a toxic amino acid that builds up when B12 is low. High homocysteine levels cause cardiovascular problems increasing the risk of atherosclerosis, hypertension, heart attack and stroke. High homocysteine is also associated with cerebral atrophy.

References:

"Everything You Want Your Doctor to Know about Vitamin B12"
http://www.youtube.com/watch?v=BvEizypoyO0

Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.
http://www.ncbi.nlm.nih.gov/pubmed/23343490

Cobalamin deficiency: clinical picture and radiological findings.
http://www.ncbi.nlm.nih.gov/pubmed/24248213

Plasma vitamin B12 status and cerebral white-matter lesions.
http://www.ncbi.nlm.nih.gov/pubmed/18977824

Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study.
http://www.ncbi.nlm.nih.gov/pubmed/15879345

The Role of B Vitamins in Preventing and Treating Cognitive Impairment and Decline
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648704/pdf/801.pdf

Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet.
http://www.ncbi.nlm.nih.gov/pubmed/20005283

Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment.
http://www.ncbi.nlm.nih.gov/pubmed/23690582

Dr. Benjamin Lynch discusses the B12 and folate methylation cycles.
https://www.youtube.com/watch?v=Mwn7RjSx3zM#t=120
Fredric-frank Myers
Posted: Monday, December 15, 2014 7:22:44 PM

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Boy oh boy, could I use some "gas" right about now.....
excaelis
Posted: Tuesday, December 16, 2014 1:51:23 AM

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Well, yes, it would be I suppose.
ChristineC
Posted: Tuesday, December 16, 2014 4:29:09 AM

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lol lol
NeuroticHellFem
Posted: Tuesday, December 16, 2014 6:58:09 AM

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This pilot study comprised only 20 patients. We're making a lot of inferences for such a small control group. Nevertheless, it sounds good so far. I've also suffered severe depression in my youth, but I'm inclined to believe it's more than merely psychological. Depression is a big killer, so it's something we need effective treatments for.
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