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King George III of England (1738) Options
Daemon
Posted: Wednesday, June 4, 2014 12:00:00 AM
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King George III of England (1738)

King George III was king of Great Britain and Ireland. During his reign, Britain lost many of its colonies in North America, and Great Britain and Ireland united to form the UK. He suffered a short nervous breakdown in 1765 and a more serious one beginning in 1788, sparking a conflict over the powers to be vested in the regency. His mental condition continued to decline, and he became permanently insane in 1810. One theory claims his condition was a result of what metabolic disorder? More...
LucOneOff
Posted: Wednesday, June 4, 2014 2:45:23 AM

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He suffered from a mental illness, which was possibly a symptom of the genetic disease porphyria.
monamagda
Posted: Wednesday, June 4, 2014 2:43:21 PM

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King George III and porphyria: an elemental hypothesis and investigation

In 1969 it was proposed that the episodic madness suffered by King George III (1738-1820) resulted from an acute hereditary porphyria, variegate porphyria, caused by deficiency of protoporphyrinogen oxidase. The diagnosis was based on the historical archive and a contentious claim that living members of the House of Hanover were affected with the condition. A re-examination of the medical evidence and the appearance of new historical material have suggested that porphyria did indeed exist in the Royal Houses of Europe. We report the analysis of hair obtained from George III. Although no genomic DNA could be obtained, metal analysis revealed high concentrations of arsenic. Since arsenic interferes with haem metabolism, it might have contributed to the King's unusually severe and prolonged bouts of illness. We have identified sources of arsenic in the context of the medication George III received from physicians.
http://www.ncbi.nlm.nih.gov/pubmed/16039338
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