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WHO Trial Finds Remdesivir Has 'No Meaningful Effect' Options
Oscar D. Grouch
Posted: Friday, November 20, 2020 5:17:41 PM

Rank: Advanced Member

Joined: 6/26/2014
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WHO Trial Finds Remdesivir Has 'No Meaningful Effect' In COVID-19 Patients
November 20, 2020 2:49 PM ET

A once-promising treatment against COVID-19 has fallen out of favor with the World Health Organization.

On Thursday, a WHO review panel issued new guidelines recommending against the use of remdesivir for COVID-19 — even though the medicine is one of the few to win regulatory approval as a treatment for the disease.

After a clinical trial in April showed that remdesivir sped up the recovery of people with severe cases of the disease, the U.S. snapped up millions of vials of the drug from its manufacturer Gilead Sciences. Over the summer, European regulators rapidly signed off on the product, leading to nations around the world signing purchase agreements for the drug. And last month, the U.S. Food and Drug administration also signed off.

Now the WHO says remdesivir doesn't do much of anything to improve the health of people hospitalized with COVID-19.

The recommendations are based on the WHO's Solidarity Trial, which is examining several coronavirus treatments including remdesivir on more than 11,000 patients in 30 countries.

The WHO panel says the data from the trial shows that remdesivir has "no meaningful effect on mortality or on other important outcomes for patients."

Remdesivir gained even more prominence in October when it was given to President Donald Trump as part of his treatment after he contracted the virus.

The WHO panel says it's possible there may be some benefit from the drug. But its relatively high cost along with the risks posed by giving it intravenously led them to recommend against using it.

The retail price of remdesivir in the U.S. was set by Gilead at $520 a dose. A typical treatment course requiring six or more doses costs thousands of dollars per patient.

The drug is given to patients as an infusion in a medical setting, which can be complicated. The infusions require a certain level of trained medical staff, who must monitor the patient and administer the drug at the right speed. Too fast and it can seep into the surrounding tissue. Infections can occur at the injection site. Ignoring the example of President Trump, who had a relatively mild case — it was only being used for hospitalized COVID-19 patients with severe forms of the disease.

Posted: Friday, November 20, 2020 9:13:01 PM

Rank: Advanced Member

Joined: 3/23/2015
Posts: 9,707
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Location: Kitchener, Ontario, Canada

Do you think maybe some of these men invested in these two drugs which are no good for Covid19 hoping to make a killing? Oops, bad choice of words, but these drugs may be good for their original purposes but not for Covid.
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